Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
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منابع مشابه
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
OBJECTIVES Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these paramet...
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Confocal laser endomicroscopy (CLE) is a newly developed endoscopic technique that enables imaging of the mucosal layer during endoscopy at a subcellular level of resolution. The method can therefore be used for the assessment of changes in vascular architecture, connective tissue, and cellular components in the mucosa, enabling endoscopists to collect real-time in vivo histological images or "...
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onfocal endomicroscopy (CLE) is a new endoscopic techique that allows to obtain high-resolution layer lining of the astrointestinal tract imaging. This technique is based on illuination of the mucosa with a laser. In this process, the laser s absorbed by a fluorescent agent and the reflected light is aptured. The laser is focused at a selected depth in the tisue of interest and the reflected li...
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BACKGROUND AND OBJECTIVES Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ile...
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ژورنال
عنوان ژورنال: Gut
سال: 2011
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2011-300695